One of the main physical causes of impotence occurs in the functioning of the brain and the nervous system. When a failure in the transmission of messages and impulses from the brain and nervous system occurs, erectile dysfunction develops. This case is very common among males with hormonal imbalance and deficiency, injury in the spinal cord, surgeries done in the pelvis, Parkinson’s disease and sclerosis. These diseases are all brain and nervous system related problems thereby resulting to a failure to make the penis erect.